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KMID : 0370219970410010111
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Yakhak Hoeji
1997 Volume.41 No. 1 p.111 ~ p.116
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Bilobalide Attenuates Glutamate-Induced Neurotoxicity in Primary Cultures of Rat Cortical Cells
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김소라/Kim SR
장영표/성상현/이흠숙/문애리/김영중/Jang YP/Sung SH/Lee HS/Moon AR/Kim YC
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Abstract
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The neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells could be attenuated by sesquiterpene constituent of Ginkgo biloba leaves, bilobalide. At the concentration of 100 nM, Bilobalide elevated the combined levels of reduced/oxidized glutathione in rat cortical cells exposed to 100mcM glutamate. Furthermore, bilobalide promoted a reduction in superoxide dismutase activity in glutamate-treated cells. Finally, bilobalide markedly inhibited the production of malondialdehyde. a measure of lipid peroxidation, in glutamate-treated rat cortical cells.
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